Study the protective effects of low-frequency pulsed electromagnetic field on neuron following cerebral ischemia-reperfusion injury in rats
- VernacularTitle:低频脉冲磁场对脑缺血再灌注损伤大鼠神经元保护作用的研究
- Author:
Hongri ZHANG
;
Boqin LI
;
Jinghua PENG
- Publication Type:Journal Article
- Keywords:
low-frequency pulsed electromagnetic field;
ischemia-reperfusion;
apoptosis;
caspase-3
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of low-frequency pulsed electromagnetic field (LFPMF) on neuron following cerebral ischemia-reperfusion injury in rats.Methods 24 adult male Sprague-Dawley rats were randomly divided into irradiation group (n=12) and control group (n=12). The global cerebral ischemia-reperfusion models of rats were produced by modified Pulsineli method. Rats in irradiation group were exposed to 20 mT intensity LFPMF of 10 Hz for 45 minutes per day for 4 days. The electroencephalogram (EEG) was recorded by powerlab system. Nissl staining was used to perform quantitative analysis of neuron number and immunohistochemistry staining provided the information of the distribution of positive cells to caspase-3.Results Compared with the control group, the amplitude of EEG was significantly higher in irradiation group [(10.27?1.12)?V versus (8.95?1.04)?V] (P
