C Reactive Protein Increases the Expression of Receptor for Advanced Glycation End-products in Human Endothelial Cells
- VernacularTitle:C反应蛋白增加人内皮细胞糖基化终产物受体表达
- Author:
Yun ZHONG
;
Xiaoqing HE
;
Minsheng CHEN
;
Shiming LIU
- Publication Type:Journal Article
- Keywords:
C-Reactive protein;
Receptor for advanced glycation end-products;
Endothelial cells
- From:
Chinese Journal of Hypertension
2007;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of C reactive protein on receptor of advanced glycation end-products protein (RAGE) and mRNA expression in human endothelial cells. Methods Human saphenous vein endothelial cells (HSVECs) were incubated with CRP. RAGE protein levels were determined by flow cytometry, and RAGE mRNA levels were assessed by RT-PCR. Results (1)Compared with control group (100%), CRP caused a significant increase in RAGE protein expression at a dose as low as 5 ?g/mL (175.2%?8.1%, P0.05). Conclusion C-reactive protein upregulates RAGE protein and mRNA expression in human endothelial cells in a dose and time dependent manner.
