Combined Irbesartan and Amiodarone in Maintaining Sinus Rhythm in Patients with Rheumatic Heart Disease after Mitral Valve Replacement
- VernacularTitle:厄贝沙坦联合胺碘酮对风湿性心脏病人瓣膜置换术后维持窦律的作用
- Author:
Ping DING
;
Li LI
- Publication Type:Journal Article
- Keywords:
Persistent atrial fibrillation, Rheumatic heart disease, Irbesartan, Amiodarone
- From:
Chinese Journal of Hypertension
2007;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of the present study was to evaluate the effect of combined irbesartan and amiodarone to maintain sinus rhythm in patients with rheumatic heart disease after valve replacement. Methods One hundred and sixteen patients of rheumatic heart disease after valve replacement operation complicated with persistent atrial fibrillation were randomized to amiodarone monotherapy (n=55) or irbesartan plus amiodarone group(n=61). Electrical cardioversion was administered 2 weeks after of pharmaceutical treatment. Patients were followed up for 18 months. Left atrial diameter was measured at before and 6, 12, 18 months after treatment. Results After 12 months, the left atrial diameter in amiodarone monotherapy group was significantly greater than irbesartan plus amiodarone combined group (P
