Advance in mechanism study of multi-drug resistance mediated by ABCC1 and its reverse
- VernacularTitle:ABCC1介导多药耐药机制及其逆转的研究进展
- Author:
Yating LI
;
Jun DOU
- Publication Type:Journal Article
- Keywords:
ABCC1;
Multi-drug resistance;
Tumor chemotherapy;
Reverse
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Multi-drug resistance(MDR) is the most frequent reason for tumor chemotherapeutic failure.ATP binding cassette(ABC) drug transporters play an important role in tumor MDR.ABCC1 is one of the members of ABC transporter super-family,which lead to drug risistance via discarding drug out of cell or changing the drug distribution in a cell.In this article,we reviewed the advance in MDR mediated by ABCC1 and its reverse.
