Inhibition of caspase-12 expression by NGF in rabbit cerebral ischemia/reperfusion injury
- VernacularTitle:NGF抑制兔脑缺血/再灌注损伤时caspase-12的表达
- Author:
Jiping YANG
;
Huaijun LIU
;
Ying LI
;
Hui LI
;
Yan LIU
;
Chunyan LI
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
nerve growth factor(NGF);
cerebral ischemia reperfusion injury;
caspase-12;
apoptosis
- From:
Basic & Clinical Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of NGF on the caspase-12 in cerebral ischemia/reperfusion. MethodsTwenty-six healthy male white rabbits were randomly divided into sham, ischemia/reperfusion and NGF group. The tissues were sampled to detect the expression of caspase-12, caspase-3 by immunohistochemistry, and to detect the cerebral apoptosis by flow cytometry and TUNEL staining methods.Results Compared with sham group, the expression of caspase-12 and caspase-3 in I/R group was higher (P
