Expression of serotonin transporters in postmortem brains of Parkinson's disease patients
- VernacularTitle:帕金森症患者脑标本5羟色胺转运体的表达
- Author:
Geming SHI
;
Ping FAN
;
Huixian CUI
;
Lei WANG
;
Wei WANG
;
Shuangcheng LI
;
Zhihong WANG
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
serotonin transporters;
immunoautoradiography;
human brain
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study serotonin transporters(SERT) in postmortem human brains of Parkinson's disease(PD).Methods Immunoautoradiography was used to show SERT distribution in postmortem PD brains.ResultsIn comparison with healthy group,SERT decreased in dorsal raphe nucleus,substantia nigra and striatum in PD brains.Quantitative analysis showed that 25.9%、31.1%、27.2% and 24.7% of labeling intensity of SERT decreased in putamen,caudate nucleus,substantia nigra and ventrotegmental area as compared with corresponding control respectively.Among the four regions studied of dorsal raphe nucleus,SERT labeling intensity significantly decreased by 38.9%,37.3%,16.5% and 37.0% of corresponding control respectively in ventral part,dorsal part,caudal part and interfascicular part.Median raphe nucleus did not show the decreased SERT labeling.ConclusionDecreased SERT expression in three regions of postmortem PD brains indicates that a dysfunction of serotonergic raphe system may contribute to the etiology of Parkinson's disease.
