Expression of ADM and ET-1 was decreased by Losartan in renal of diabetic rats
- VernacularTitle:氯沙坦降低糖尿病大鼠肾脏肾上腺髓质素和内皮素的表达
- Author:
Feng GAO
;
Qingjuan LIU
;
Huijun DUAN
;
Yanping CAO
;
Yonghong SHI
;
Lihui WANG
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
adrenomedullin;
endothelin;
losartan
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of Losartan on ADM,ET-1 and their receptors in the kidney of diabetic rats.Methods Experimental diabetes was induced in uninephrectomized rats by STZ.The animals were divided into three groups: group A(control group),group B(diabetic group) and group C(Losartan-treated group).Immunohistochemistry,Western bloting,in situ hybridyzation and RT-PCR were used to detect the protein and mRNA expressions of ADM,ADMR,ET-1 and EDNR-A.Results Compared with group A,the expressions of ADM,ADMR,ET-1 and EDNR-A in group B significantly increased.After Losartan treatment,those indicators decreased.Conclusion The expressions of ADM,ET-1 and their receptors may be responsible for the renal protective effect of Losartan in diabetic rats.
