Effects of Buchang Naoxintong on cognitive function and apoptosis of cranial nerve cell in vascular dementia rats induced by chronic ischemia
- VernacularTitle:步长脑心通对慢性脑缺血致血管性痴呆大鼠认知功能及神经细胞凋亡的影响
- Author:
Bing SUN
;
Jiang WU
;
Chunkui ZHOU
;
Shaokuan FANG
- Publication Type:Journal Article
- Keywords:
Buchang Naoxintong;
dementia,vascular;
apoptosis;
genes,bcl-2
- From:
Journal of Jilin University(Medicine Edition)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Buchang Naoxintong on cognitive function and apoptosis of cranial nerve cells in vascular dementia rats induced by chronic ischemia and their mechanisms.Methods The permanent occlusion of bilateral common carotid arteries in Wistar rats was adopted to set up the chronic fore-brain ischemia model.Model rats were randomly divided into model control groups and drug groups at 1 and 2 month,unoperated Wistar rats were divided into normol control groups at 1 and 2 month,six rats in each group.The cognitive function was assessed by Morris water labyrinth.The morphologic changes of cranial nerve cells were observed with HE staining.The apoptosis was examined by methods of TUNEL,the expression of Bcl-2 protein was detected by immnunohistochemistry method.Results Compared with model control group,escape incubation periods in drug group at 1 and 2 month were shorter(P
