Expressions of APC,bcl-2 and c-met in gastric cancer and its precancerous lesion and their significances
- VernacularTitle:胃癌及胃癌前病变中APC、bcl-2和c-met基因的表达及意义
- Author:
Yixia LU
;
Xiping ZHU
;
Yanhong LU
;
Baorong CHI
- Publication Type:Journal Article
- Keywords:
gastric neoplasms;
precancerous conditions;
genes,APC;
genes,bcl-2;
proto-oncogene protein c-met;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the expressions of APC,bcl-2 and c-met gene in the progress of gastric cancer and their significances in the diagnosis of early gastric cancer.Methods The immunohistochemical technique was used to detect the expressions of APC,bcl-2 and c-met gene in 30 cases of human gastric carcinoma(GC),30 cases of intestinal metaplasia(IM),30 dysplasia(Dys) gastric mucosa,10 gastric adenoma(GA) and 20 normal gastric mucosa.Results ①The positive expression rates of APC in GC,IM,Dys and GA(53.3%,67.7% and 53.3%,respectively) were significantly lower than those in normal gastric mucosa(90.0%,P
