Expressions of VEGF and TGF-? in periosteum in patients with congenital pseudarthrosis of tibia
- VernacularTitle:VEGF和TGF-?在先天性胫骨假关节患者骨膜中的表达
- Author:
Shuqiang LI
;
Ping WANG
;
Yaqin YU
;
Xin ZHANG
;
Dongsong LI
- Publication Type:Journal Article
- Keywords:
congenital pseudarthrosis of tibia;
endothelial growth factor;
transforming growth factor beta;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To approach the expressions of vascular endothelial growth factor(VEGF) and transforming growth factor-beta(TGF-?) in periosteum in patients with congenital pseudarthrosis of tibia(CPT) and elucidate the pathogenesis possibility.Methods The expressions of VEGF and TGF-? in 19 specimens from patients with CPT were detected by using immunohistochemical method.Ten normal periosteum from the healing site after tibia fracture were taken as negative group;15 fresh periosteum from the close tibia fractures were positive group.Results VEGF and TGF-? expressed in vascular endothelial cytoplasm of periosteum.The expression levels of VEGF and TGF-? of CPT were lower than those in positive group(P0.05).Conclusion The decreasing of expression levels of VEGF and TGF-? in periosteum may be involved in pathogenesis of CPT.
