Effect of Atorvastatin on Endothelial Function in Hypertensives Without Hyperlipemia
- VernacularTitle:阿托伐他汀对血脂正常高血压患者血管内皮功能的影响
- Author:
Yan LU
;
Yinong JIANG
;
Haiyan CUI
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Lipid;
Hypertension;
Endothelial function;
Atorvastatin
- From:
Chinese Journal of Hypertension
2007;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different dose of atorvastatin on endothelium dependent vasodilatation function in hypertensives without hyperlipemia in attempt to verify the hypothesis of "beyond antihyperlipimia" effect of statins.Methods Fifty-five hypertensives without hyperlipemia were randomly to receive atorvastatin(10 mg/d,n=25)or(20 mg/d,n=30).Twenty-five normotensives were enrolled in control group.Serum cholesterol were determined.Flow-mediated dilation(FMD)and endothelium-independent dilatation(EID)were measured with high-resolution ultrosonography before and after 4 weeks atorvastatin.Results Compared with control group,FMD were significant decreased in hypertensives without hyperlipemia.FMD were improved after atorvastatin for 4 weeks(atorvastatin 10 mg group:7.5%?2.7% vs 11.5%?3.1%,P
