Sodium Channel Current In Hypertrophied Myocardiocytes in Spontaneously hypertensive Rat
- VernacularTitle:肥厚心肌细胞钠通道电流
- Author:
Zhibin HUANG
;
Wei WU
;
Chang FANG
;
Yulin WEI
- Publication Type:Journal Article
- Keywords:
Hypertension;
Left ventricular hypertrophy;
Ionic channel;
Sodium channel
- From:
Chinese Journal of Hypertension
2007;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change in sodium channel current(ⅠNa)in the developement of the left ventricular hypertrophy in spontaneously hypertensive rat(SHR).Methods ⅠNa and membrane capacitance(MC)were measured in myocytes of 10,24 and 34-week SHR by the whole-cell patch-clamp technique.Systolic blood pressure(SBP)and left ventricular mass index(LVMI)were detemined.10-week old Wistar rats served as controls.Results LVMI and MC of SHR were significantly higher than those of Wistar rat(P0.05),however the density of ⅠNain 34-week SHR were higher than those of Wistar rat(-18.3?1.9)vs(-15.3?2.0)pA/pF,P
