Association between Dopamine Receptor D4 Polymorphisms and Novelty Seeking Personality Trait in a Korean Population.
- Author:
Heon Jeong LEE
1
;
Hong Seock LEE
;
Hwa Yeon KANG
;
Leen KIM
;
Min Soo LEE
;
Kwang Yoon SUH
;
Young Chan BYUN
Author Information
1. Department of Psychiatry, Eumsung Mental Hospital, Chungbuk Province, Korea.
- Publication Type:Original Article
- Keywords:
Novelty seeking;
Polymorphism;
DRD4
- MeSH:
Dopamine*;
Exons;
Female;
Humans;
Receptors, Dopamine*;
Temperament
- From:Journal of Korean Neuropsychiatric Association
2002;41(4):630-637
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We investigated the relationship of personality traits with dopamine D4 receptor(DRD4) exon III polymorphism in a Korean population. METHODS: We analysed DRD4 exon III 48-bp repeats polymorphism in 173 Korean healthy female adolescents(age=13.88+/-0.29 years) who also completed Temperament and Character Inventory(TCI). RESULTS: Novelty seeking score of the TCI was significantly higher in the subjects with DRD4 long alleles(>or=5 repeats) compared with the subjects without these(t=2.11, p=0.037). CONCLUSION: The present study supports the previous reports that long repeats of the DRD4-exon III polymorphism are related with Novelty Seeking personality.
