Therapeutic drug effects or toxicity depends on genetic polymorphisms in cancer chemotherapy
- VernacularTitle:基因多态性影响肿瘤化疗药物疗效或毒性作用的研究进展
- Author:
Yuxia DENG
;
Xinchen SUN
- Publication Type:Journal Article
- Keywords:
Genetic polymorphism;
Chemotherapeutics drugs;
Cancer
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
A nucleotide diversity in DNA sequence is called polymorphism,which results in intersubjects variation in therapeutic drug effects and toxicity.Clinical studies were found that a single nucleotide polymorphism influenced response or drug toxicity in cancer chemotherapies,which were based on 5-fluorouracil,Irinotecan,platinum and so on.This review will focus on the recently development in the relation between drug effects or toxicity and polymorphism.
