Research development on drug-resistance mechanism of taxanes
- VernacularTitle:紫杉类药物耐药机制的研究进展
- Author:
Hai SHUN
;
Jian GENG
;
Longbang CHEN
- Publication Type:Journal Article
- Keywords:
Taxanes;
Drug resistance
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Drug resistance is the main restriction factor for clinical usage of taxanes.This review concentrates on drug-resistance mechanisms of taxanes that include drug target change,avidity change between drug-target interaction,decrease of cellular effective drug concentration,downstream cellular responses to a drug target molecular lesion,and cell cycle regulation-mediated drug resistance.
