Progress in the study of thin basement membrane nephropathy
- VernacularTitle:薄基膜肾病的研究现状
- Author:
Ming CHENG
;
Zheng TANG
- Publication Type:Journal Article
- Keywords:
Thin basement membrane nephropathy;
Alport syndrome;
Genetics;
Pathogenesis
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Thin basement membrane nephropathy(TBMN) is one of the most common disorders of the kidney,affecting at least 1% of the population.It seems to be a disease of the adult glomerular basement membrane(GBM) type Ⅳ collagen trimer ?3∶?4∶?5.Genetic evidence indicates that autosomal TBMN is caused by heterozygous mutations in either COL4A3 or COL4A4, whereas homozygous or combined heterozygous mutations in the same genes lead to autosomal recessive Alport syndrome.The author summarized the epidemiology,clinical features,renal biopsy,genetics,pathogenesis,diagnosis and therapy of TBMN.
