Mitochondrial permeability transition pore and myocardial ischemia-reperfusion injury
- VernacularTitle:线粒体通透转换孔与心肌缺血-再灌注损伤
- Author:
Xiaoming LIU
;
Jianguo XU
- Publication Type:Journal Article
- Keywords:
Mitochondrial permeability transition pore;
Ischemia-reperfusion injury;
Myocardial ischemic preconditioning
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion of the heart leads to the opening of mitochondrial permeability transition pore(MPTP).Transient opening and subsequent closure of the MPTP may lead to the release of cytochrome c and other proapoptotic molecules.If unrestrained,this will lead to the loss of ionic homeostasis and initiate the cascade of necrotic cell death.Direct or indirect inhibition of MPTP provides protection against ischemia-reperfusion injury.Recent researches have shown that transient low-conductance pore opening also provides protection against reperfusion injury.This review gives summarization of the components,molecular mechanism of MPTP,permeability transition in myocardial ischemia-reperfusion and the relationship between MPTP and ischemic preconditioning.This may lead to better protective strategies against myocardial ischemia-reperfusion injury in the future.
