Study on ratio of CD4/CD8 and the number of CD4~+ CD25~+ Treg cells in PBMC of rheumatoid arthritis patients
- VernacularTitle:RA患者外周血CD4/CD8 T细胞比值及CD4~+ CD25~+ T细胞的检测及其临床意义
- Author:
Yun WANG
;
Xinguo CAO
;
Liwen WANG
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
CD4/CD8;
CD4+ CD25+ Treg cell
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the ratio of CD4+ and CD8+ T cells and the number of CD4+CD25+ T regulatory cells(Treg)in human peripheral blood mononuclear cells(PBMC)of rheumatoid arthritis(RA)patients and evaluate the significance for diagnosis of RA.Methods The number of CD4+,CD8+ T cells and Treg cells were detected by flow cytometry and the ratio of CD4/CD8 was calculated.Results The ratio of CD4/CD8 and the number of CD4+CD25+ T cells detected in 49 RA patients were significantly higher than that in health group with statistical significance(P
