Cognitive Deficits and Oxidative Stress in Male Patients with Heroin Dependence
- VernacularTitle:男性海洛因依赖者认知功能状况与氧化应激的关系
- Author:
Wu LI
;
Wei HAO
;
Chunfeng HU
- Publication Type:Journal Article
- Keywords:
substance dependence;
heroin;
case-control study;
cognitive function;
oxidative stress
- From:
Chinese Mental Health Journal
1989;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between cognitive deficits and oxidative stress in male patients with heroin dependence (MPHD). Methods: The cognitive function of 140 MPHD and 75 healthy controls were evaluated with Wechsler Memory Scale (WMS), Cancellation Test (CT) and Modified Wisconsin Card Sorting Test (M-WCST). The levels of serum nitric oxide (NO) and malondialdehyde (MDA) were detected in colorimetry. Results:The performances of WMS, CT and M-WCST in MPHD were significantly lower than that in healthy controls (93.7?13.8/102.9?12.3, t=-2.83; 161.6?32.8/194.4?26.5, t=-4.28; 18.8?7.8/25.0?7.5, t=-3.38, P
