Research on the relation between the content of thiol group and in vitro adhesion of the chitosan-thioglycolic acid conjugates
- VernacularTitle:壳聚糖-巯基醋酸偶合物的巯基含量与体外黏附性关系研究
- Author:
Ganjun YUAN
;
Qiuling SU
;
Hongqian HUANG
;
Xingliang SHEN
;
Mingsheng LIU
;
Demei CHEN
- Publication Type:Journal Article
- Keywords:
chitosan-thioglycolic acid conjugates;
thiol group;
adhesion
- From:
Chinese Journal of Marine Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Research on the relation between the content of thiol group in chitosan-thioglycolic acid conjugates and in vitro adhesion. Methods Prepared chitosan-thioglycolic acid conjugates with different content of thiol group,and determined the swelling behavior,instant detachment force between test disc and mucosa,recorded the maximum detachment force(MDF),and calculated the total work of adhesion(TWA)of these samples.Results The relation between the content of thiol groups and in vitro adhesion of the chitosan-thioglycolic acid conjugates was positive correlation, the adhesion of the polymer increased along with the content of thiol group,but the rate decreased.Conclusion The adhesion of chitosan-thioglycolic acid conjugates with higher content of thiol gyoup was far more stronger than chitosan.
