Study on lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice
- VernacularTitle:羧甲基壳聚糖钙对染铅小鼠治疗性排铅作用的研究
- Author:
Jinxin CHU
;
Baoqin HAN
;
Wendi CAI
;
Changhong WANG
;
Wanshun LIU
- Publication Type:Journal Article
- Keywords:
carboxymethyl chitosan calcium(CCC);
lead poisoning;
antioxidation
- From:
Chinese Journal of Marine Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of carboxymethyl chitosan calcium(CCC) on the concentration of lead,calcium,and liver antioxidative capacity in lead poisoned mice.Methods mice were randomly divided into 6 groups.Three test groups were treated with CCC at three doses.The lead poisoned mice model was established by giving water containing lead acetate,and then CCC was administered to mice once a day.After 30 days,the mice were killed and the content of lead in blood,liver,brain and femur were determined by atomic absorption spectrophotometer,and antioxidative capacity in liver was measured using assay kit.Results CCC could reduce the contents of lead in blood,brain,liver and femur significantly,decrease the level of maleicdialdehyde(MDA),increase activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and total antioxidative capacity(T-AOC) in liver markedly. Conclusion CCC can promote the excretion of lead,increase the content of calcium in femur and antioxidative capacity in lead poisened mice.
