Research advance of protein fingerprinting technology in laboratory diagnosis and clinical medicine
- VernacularTitle:蛋白质指纹图谱技术在实验诊断与临床医学中的研究进展
- Author:
Yang XU
- Publication Type:Journal Article
- Keywords:
protein fingerprinting technology;
laboratory diagnostic technology;
immunomic mass spectrometry
- From:
Basic & Clinical Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Protein fingerprinting technology(PFT) is a novel technology for laboratory diagnosis developed in recent five years.It has advantages of simple operation,testing quickly,high sensitivity and specificity.It is a revolutional progress for laboratory diagnosis.The application of PFT in medical field is mainly for the detection of diseases.The sensitivity and specificity in cancer detection are about 80%.Immunomic mass spectrometry(IMS) is a novel technology using the combined group antibodies for capture multi biomarkers and applying mass spectrometry to precisely analyze the modification or isoforms of the biomarker in single platform,whereas traditional assay could not be able to identify the variation of biomarkers.PFT and IMS have significantly influenced in cancer early detection,especially to evaluate cancers which did not express traditional tumor markers like AFP,CEA,etc.PFT and IMS have characteristics of early detection in the molecular and gene level.PFT and IMS are diagnostic technologies with bright future and potential applications.
