Relationship of expressions of EphrinB2 and angiogenesis in human colorectal carcinoma
10.3760/cma.j.issn.1006-9801.2010.07.011
- VernacularTitle:结直肠癌组织EphrinB2的表达与血管生成的关系
- Author:
Jingfu SUN
;
Keping FEI
;
Chensheng LI
;
Hongjun LIU
;
Yulong SHI
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Receptor,EphrinB2;
Angiogenesis;
Microvessel density;
Immunohistochemistry
- From:
Cancer Research and Clinic
2010;22(7):464-465,472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of EphrinB2 and microvessel density(MVD) in colorectal carcinoma and to analyze the relationship between the expression of EphrinB2 and the biological characteristics of colorectal carcinoma. Methods EphrinB2 and MVD of 63 colorectal carcinoma diagnosed by pathology were examined by immunohistochemistry, and 25 specimens from normal colorectal tissue were examined as controls. Results The expression of EphrinB2 protein was 82.0 % (51/63) in colorectal carcinoma and 32.0 % (8/25) in the normal colorectal tissues, the difference was significant (P <0.05). Meanwhile, MVD was significantly higher in EphrinB2 positive group (39.39±8.97) than that in negative group (33.00 ±10.19) (P<0.05). The expression of EphrinB2 protein had significant positive correlation with differentiation grade, infiltration, lymph node metastases and clinical stage (P <0.05), and had no relation to age, sex, tumor size and location(P >0.05). Conclusion The EphrinB2 protein expression increase may be involved in development of colorectal carcinoma and play important roles in the tumorigenesis and progression of colorectal carcinoma.
