Application of anti-CD20 monoclonal antibody in the treatment of active systemic lupus erythematosus
- VernacularTitle:抗CD20单克隆抗体治疗活动性系统性红斑狼疮
- Author:
Jie LI
;
Xuejun ZENG
- Publication Type:Journal Article
- Keywords:
systemic lupus erythematosus;
Anti-CD20 monoclonal antibody
- From:
Basic & Clinical Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To identify the clinical efficacy,immunological consequences and adverse effects of anti-CD20 monoclonal antibody in systemic lupus erythematosus.Nearly 100 patients have been reported and a 80% of them achieved marked reduction in global disease activity and clinical remission in lupus nephritis.Anti-CD20 monoclonal antibody is well tolerated in 90% of the patients,though10% of them had hypersensitivity reactions and 4 patients had severe opportunistic infection.
