Effect of glucocorticoid/glucocorticoid receptor on homeostasis of cell number
- VernacularTitle:糖皮质激素及其受体对细胞数量稳态调节的作用
- Author:
Jian LU
- Publication Type:Journal Article
- Keywords:
glucocorticoid;
glucocorticoid receptor;
antiproliferation;
antiapoptosis
- From:
Basic & Clinical Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Glucocorticoid(GC) /glucocorticoid receptor(GR) inhibits cell proliferation and protects cells from apoptosis induced by serum deprivation,hypoxia,irradiation or chemotherapy drugs in many cell types,thereby GC/GR can maintain cell number homeostasis,which is an important aspect of homeostasis regulation of GC/GR in higher organisms.This article reviews antiproliferative and antiapoptotic effects of GC/GR on cell and their molecular mechanism,mainly focusing on the molecular events and target genes downstream of GC/GR.
