Study on the Changes of Soluble Intercellular Adhesion Molecule-1 Level in Sera of Rats Infected with Pneumocystis carinii
- VernacularTitle:感染卡氏肺孢子虫大鼠血清中可溶性细胞黏附分子-1(sICAM-1)变化的研究
- Author:
Keqin LIU
;
Weidong YIN
;
Guiping XUE
;
Jinshun ZHANG
- Publication Type:Journal Article
- Keywords:
Pneumocystis carinii;
Rat;
Soluble intercellular adhesion molecule-1(sICAM-1);
Histopathology
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To examine sICAM-1 in Pneumocystis carinii pneumonia(PCP) and the effect of TMP-SMZ therapy on its level and on pathological and immunological changes in rats.Methods 50 female Wistar rats were randomly divided into normal group(N group),PCP model group(PCP group) and TMP-SMZ therapy group(SMZ group).1 mg of dexamethasone was injected intramuscularly twice a week for rats in PCP and SMZ groups to induce PCP.Normal saline was injected for N group in the same way.When the infection was confirmed,TMP-SMZ was given to rats in SMZ group by 25 mg/(kg.d) for 5 days for 3 courses with an interval of 2 weeks.sICAM-1 in serum was detected by ELISA,and the pathological changes in lungs and liver and the Pc in alveoli of lungs were observed.Results The level of sICAM-1 in PCP and SMZ groups at the 3rd week [(1.847?0.50) ng/ml,(1.787?0.59) ng/ml] was lower notably than that at 0 week[(2.407?0.81) ng/ml,[(2.478?0.59) ng/ml respectively](P0.05).Conclusion The sICAM-1 level in rats was low but significantly increases after the induction of PCP.
