Relationship between the angiotensin Ⅱ type 1 receptor gene polymorphisms and cerebrovascular disease
- VernacularTitle:血管紧张素Ⅱ受体-1基因多态性与脑血管病的关系
- Author:
Jiling HE
;
Yongfu WANG
;
Guoan YANG
- Publication Type:Journal Article
- Keywords:
angiotensin Ⅱ type 1 receptor;
gene polymorphism;
cerebrovascular disease
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between angiotensin Ⅱ type 1 receptor (AT1R) gene polymorphisms and cerebrovascular disease (CVD).Methods The 104 patients with CVD and 98 healthy individuals were detected the AT1R genotypes polymorphisms by restriction fragment length polymorphism in order to analysis.Results CC genotype was not found both in CVD and control group. In CVD group, genotypic frequency of AA was 40.4% and AC was 59.6%. The allele frequency of A was 70.1% and C was 29.9%. In control group, genotypic frequency of AA was 91.8% and AC was 8.1%. The allele frequency of A was 95.9% and C was 4.1%. AT1R polymorphism revealed there was significant difference between the genotype and allelic distribution in CVD patients and those of in controls (all P
