Efficacy and safety of intravenous and intra-arterial thrombolytic therapy in acute ischemic stroke
- VernacularTitle:动脉溶栓与静脉溶栓治疗急性脑梗死的有效性和安全性
- Author:
Yun HE
;
Lili MA
;
Ruimin FAN
- Publication Type:Journal Article
- Keywords:
acute cerbral infarction;
thrombolytic therapy;
intra-arterial and intravenous;
efficacy;
safety
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy and safety of intravenous and intra-arterial thrombolytic therapy in acute cerebral infarction(ACI).Methods 65 patients with ACI were randomly divided in two groups:intra-arterial thrombolytic group (n=21) were intra-arterially administed with 250 000-500 000 units urokinase through femoral artery and intravenous thrombolytic group (n=44) were intravenously administed with 1.5 million units urokinase.Before and after treating, their neurological deficit scales were evaluated. The thrombin time (TT), prothrombin time (PT) and fibrinogen were detected before and after thrombolysis 6 h,3 d and 7 d.The CT scan was rechecked after thrombolysis 24 h.Results (1)ESS scales were higher in the intra-arterial infusion group than those in the intravenous infusion group at 2h, 6h, 24h, and 3d (all P
