Changing features of microtubule associated protein 2 expression in hippocampal dentate gyrus of epileptic rats and the intervention results after using Diazepam
- VernacularTitle:癫癎大鼠海马齿状回微管相关蛋白2表达规律及地西泮干预的研究
- Author:
Shengjun WANG
;
Zhaofu CHI
;
Wen CHEN
- Publication Type:Journal Article
- Keywords:
epilepsy;
MAP2;
Diazepam;
Pentylenetetrazol
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changing features of microtubule associated protein 2 (MAP2) expression, which was a neural dendrite marker, of epileptic rat and the intervention results after using Diazepam. The relations between MAP2 and epileptogenesis were also explored.Methods Model of epileptic rat was established by Pentylenetetrazol (PTZ) and divided into PTZ-NA group,PTZ-Diazepam group, Diazepam-PTZ group and normal control group. Immunohistochemistry method was applied on hippocampus of epileptic rats to determine the change of MAP2 immunoreactivity (MAP2-IR) with or without Diazepam intervention at various time points. MAP2-IR was showed by mean optical density (COD).Results In the PTZ-NA group and PTZ-Diazepam group, MAP2-IR in molecular cell layer of hippocampal dentate gyrus increased after 3 days (all P
