Changes and its significance of neuron-specific enolase and myelin basic protein in serum after seizure of rats with temporal epilepsy
- VernacularTitle:颞叶癫癎大鼠癎性发作后神经元特异性烯醇化酶、髓鞘碱性蛋白的变化及其意义
- Author:
Jihong TANG
;
Siming HU
;
Qin GU
- Publication Type:Journal Article
- Keywords:
epilepsy;
neuron-specific enolase;
myelin basic protein;
kainic acid
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the dynamic changes of neuron-specific enolase (NSE) and myelin basic protein (MBP) in serum of rats with temporal epilepsy (EP) induced by kainic acid (KA) and to judge the degree of injury of brain neuron and nerve myelin after seizure.Methods KA was injected into rat's hippocampus by stereotactic operation to establish an animal model of temporal EP.The levels of NSE and MBP in serum of rats with temporal EP were measured at the time 3 h,6 h,12 h,24 h,48 h and 72 h after seizure.Results The level of NSE in serum increased gradually and reached its peak at 24 h after seizure, as well as MBP at 72 h.Conclusions There are the nerve cell damage and necrosis after seizure in rats with temporal EP, then brain white matter nerve myelin appear to damage.
