Clinical and pathological features of leprous neuritis (report of 1 case)
- VernacularTitle:麻风性神经炎的临床与病理特征(附1例报告)
- Author:
Xia CAO
;
Bingzhen CAO
;
Chuanzhu YAN
- Publication Type:Journal Article
- Keywords:
leprous neuritis;
biopsy;
pathology
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical and pathological features of leprous neuritis.Methods Sural nerve biopsied specimens from one patient with leprous neuritis were analyzed with histopathology and electron microscopy.Results The main clinical characteristics included injuries of sensory nerves with numbness and pain in the distal limbs, vegetative nerve functional disturbance, and the asymmetrical bulky ulnar nerve. The pathological changes were the presence of lymphocytic infiltrates in the endoneurial and epineurial spaces, a mild stenosis of small vessel with a large number of perivascular lymphocytic and mononuclear phagocytic infiltrates combined with epithelioid cells form. Anti-acid staining demonstrated the positive leprosy bacillus in nerve fibers. A nearly completely loss of myelinated fibers and obvious connective tissue proliferation were also seen in the sural nerve. The electron microscopy observed marked axonal degeneration of unmyelinated nerve fibers with many leprosy bacillus in Schwann' cells. This case was treated with Aminophenylsulfone and Dehydrocortisone for one year and his condition had improved.Conclusions Diagnosis of leprous neuritis depends on the nerve biopsy, and the early treatment may relieve disability.
