Effect of Simvastatin on Plasma Malondialdehyde LDL (MDA-LDL) and Pregnancy-Associated Plasma Protein (PAPP-A) in Patients of Coronary Heart Disease
- VernacularTitle:辛伐他汀对冠心病人丙二醛化低密度脂蛋白、妊娠相关蛋白酶-A的影响
- Author:
Zhihui ZHANG
;
Xuping LI
;
Kan YANG
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Angiography;
MDA-LDL;
Coronary;
PAPP-A;
Oxidative stress;
Simvastatin
- From:
Chinese Journal of Hypertension
2007;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine plasma levels of MDA-LDL and pregnancy-associated plasma protein-A in patients with angiography type lesions Ⅱ(representing plaque rupture with or without thrombosis), and to evaluate the effect of simvastatin on plasma MDA-LDL and PAPP-A. Methods One hundred and ten patients were enrolled and underwent coronary angiography with 85 patients diagnosed as coronary heart disease (CHD) and twenty-five as controls. According to the morphologic types of plaque, the patients with CHD were straitified as type Ⅰ(smooth borders) (n=31) and type Ⅱ(irregular lesions) (n=35) and type Ⅲ (long lesions with irregular surface) group (n=19). The patients in type Ⅱ group received simvastatin (40 mg/d ) for four weeks. The plasma MDA-LDL, PAPP-A, LDL, HDL levels before and after simvastatin treatment were determined. Results Plasma levels of MDA-LDL, PAPP-A in type Ⅱ group was significantly higer than that in the controls group, type Ⅰ group, type Ⅲ group (P