The Role of TNF-alpha in Eosinophilic Inflammation of RSV Bronchiolitis.
- Author:
Jungi CHOI
1
;
Kyung HUH
;
Hyo Bin KIM
;
Un Ki YOUN
;
Chang Keun KIM
Author Information
1. Department of Pediatrics and Asthma Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea. kimck@sanggyepaik.ac.kr
- Publication Type:Original Article
- Keywords:
Tumor necrosis factor-alpha;
Respiratory syncytial virus;
Eosinophilic inflammation;
Bronchiolitis
- MeSH:
Asthma;
Bronchiolitis;
Chemokines;
Chemokines, CC;
Child;
Cytokines;
Eosinophil Cationic Protein;
Eosinophil-Derived Neurotoxin;
Eosinophils;
Granulocyte-Macrophage Colony-Stimulating Factor;
Granulocytes;
Humans;
Inflammation;
Interferons;
Interleukin-8;
Interleukins;
Nasal Lavage Fluid;
Respiratory Syncytial Viruses;
Respiratory Tract Infections;
Tumor Necrosis Factor-alpha
- From:Pediatric Allergy and Respiratory Disease
2008;18(1):46-53
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Tumor necrosis factor (TNF)-alpha and eosinophilic inflammation have their role in asthma, but there were no studies on respiratory syncytial virus (RSV) bronchiolitis. The aim of our study was to investigate whether TNF-alpha has a role in eosinophilic inflammation of lower respiratory tract infections with RSV and has the correlation with other cytokines. METHODS: Fifty children with first RSV bronchiolitis (RSV group) and 18 healthy children without any respiratory symptom and sign (control group) were enrolled. Clinical data, such as eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), were analyzed. We measured interleukin (IL)-5, IL-8, TNF-alpha, granulocyte macrophage-colony stimulating factor (GM-CSF), interferon (IFN)-gamma, eotaxin, and regulated on activation, normal T cell expressed and secreted (RANTES) in nasal lavage fluid in both groups. RESULTS: Eotaxin, GM-CSF, IL-8, IFN-gamma and TNF-alpha were higher in the RSV group than the control group. TNF-alpha correlated with an eosinophil-active cytokine, GM-CSF (r=0.86, P<0.0001), IFN-gamma (r=0.90, P<0.0001), and with eosinophil-active C-C chemokines such as eotaxin (r=0.50, P<0.0001). TNF-alpha also correlated with proinflammatory cytokines such as IL-8 (r= 0.81, P<0.0001). CONCLUSION: TNF-alpha correlated with eosinophil-active chemokines and cytokines. Therefore, TNF-alpha may have a role in eosinophilic inflammation in children with RSV bronchiolitis.
