Biological Characteristics of Acid Sensing Ion Channels (ASICs) and Their Modulations
- VernacularTitle:酸感受性离子通道生物学特性及其调控
- Author:
Xiechuan WENG
;
Jianquan ZHENG
;
Shuangqing PENG
;
Jin LI
- Publication Type:Journal Article
- Keywords:
acid sensing ion channel (ASIC), biological characteristic, sodium channel, function, modulation
- From:
Progress in Biochemistry and Biophysics
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
ASICs are H+-gated novel cation ion channels, which belong to the epithelial sodium channels (NaC/DEG) superfamily. As recent studies focus, ASICs are expected to be pharmacological targets on protecting the neuron from ischemia and damage, improving the ability of memory and study, curing epilepsy and analgesia. It is not until the most recentness that the subunits of ASICs have been cloned. Now, researchers have paid more attention to the distribution, expression, function and modulation of ASICs in the organism.
