Effect of adrenomedullin on proadrenomedullin N-terminal 20-peptide and hypoxic pulmonary vascular structural remodeling in rats
- VernacularTitle:低氧大鼠肾上腺髓质素对其前体N端20肽和肺血管结构重构的影响
- Author:
Yaguang DING
;
Jianguang QI
;
Chaoshu TANG
;
Junbao DU
- Publication Type:Journal Article
- Keywords:
adrenomedullin;
proadrenomedullin N-terminal 20-peptide;
hypoxia;
pulmonary hypertension
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of adrenomedullin(ADM) on hypoxic pulmonary vascular structural remodeling and proadrenomedullin N-terminal 20-peptide(PAMP) in rats with hypoxic pulmonary hypertension.Methods Twenty-four male Wistar rats were randomly divided into control group(n=8),hypoxia group(n=8) and hypoxia with ADM group(n=8).ADM was subcutaneously administered into rats of hypoxia with ADM group by mini-osmotic pump(300 ng/h).The concentration of plasma PAMP was measured by radioimmunoassay,and the expression of PAMP in pulmonary artery was detected by immunohistochemical assay.Results Mean pulmonary arterial pressure,the ratio of right ventricular mass to left ventricular plus septal mass,and relative medial thickness and relative medial area of pulmonary arteries significantly increased in hypoxic rats as compared with that of controls(P
