Association of aldosterone synthase gene -344C/T polymorphism with left ventricular structure and function in patients with essential hypertension
- VernacularTitle:原发性高血压患者醛固酮合酶基因-344C/T多态性与左室结构及功能的关系
- Author:
Xiaojun HU
;
Yuanchao TU
;
Su CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
110 g/m2 in females.④Logistic regression analysis was conducted taking sex, age, body mass index, body surface area, blood pressure, blood fat level, plasma aldosterone concentration and aldosterone synthase as independent variables while LVEDD, LVM or LVH as dependent variables respectively. RESULTS: All 68 patients were involved in the result analysis.①Among 68 cases of essential hypertension, there were 36 cases for TT genotype, 28 cases for CT genotype and 4 cases for CC genotype. And they were divided into TT genotype group and CT+CC genotypes group.②Compared with those subjects with TT genotypes, hypertensive subjects with CT+CC genotypes had a higher LVEDD, LVM and LVM index [(50.2?3.2) mm, (48.1?3.2) mm; (220.8?34.4) g, (197.4?35.5) g; (123.4?21.5) g/m2, (107.2?15.9) g/m2; t =2.73, 2.74, 3.54, P
