Therapeutic effect of Donepezil hydrochloride on Alzheimer's disease rats
- VernacularTitle:盐酸多奈哌齐对D-半乳糖致老年性痴呆大鼠治疗作用的机制
- Author:
Xianglin XIE
;
Hongyan LIU
;
Hongbin ZOU
;
Ye LI
;
Kai LIU
- Publication Type:Journal Article
- Keywords:
Donepezil hydrochloride;
Alzheimers disease;
D-galactose;
learning and memory;
rat;
free radicals
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of therapeutic effect of Donepezil hydrochloride on Alzheimer's disease(AD) rats.Methods According to weight,36 rats were divided into normal group,model group and Donepezil hydrochloride group.AD rat model was set up by injecting D-galactose into abdominal cavity for seven weeks,learning and memory function of rats was determined by using Morris water maze and Step-down test.The section of rat cerebral cortex and hippocampus were stained with haematoxylin eosin(HE),and the effect of Donepezil hydrochloride was observed by detecting the MDA content and SOD activity in cerebral tissue.Results Compared with model group,latency and distance of Donepezil hydrochloride rats shortened on the fourth day and the fifth day,starting angle of Donepezil hydrochloride rats shortened on the fourth day and the fifth day in the Morris water maze test,error times of Donepezil hydrochloride rats decreased on the first day and the second day in Step-down test;MDA content in cerebral tissue of Donepezil hydrochloride rat was deceased(P
