Detection of chemokines in patients with Kawasaki disease and Henoch-Schonlein purpura and its clinical significance
- VernacularTitle:川崎病与过敏性紫癜患儿血浆趋化因子的检测及临床意义
- Author:
Jian CHANG
;
Xin ZHAO
;
Dong LIANG
;
Yinbo CHEN
;
Jirong LU
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
mucocutaneous lymph node syndrome;
Henoch-Schonlein purpura;
chemokine
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and clinical significances of the chemokines of interferon-?-inducible protein-10(IP-10),monocyte chemoattractant protein-1(MCP-1) and growth-related oncogene-?(Gro-?) involved in pathagenesis of Kawasaki disease(KD) and HenochSchonlein purpura(HSP).Methods The chemokines production of IP-10,MCP-1 and Gro-? were assayed by ELISA in 15 patients with KD,12 patients with HSP and 10 healthy children.Results The plasma levels of IP-10 and MCP-1 were markedly elevated in KD group [(394.2?176.4)and(420.5?163.4)ng?L-1]compared with HSP group[(94.8?66.4)and(109.2?76.6)ng?L-1] and the control group [(76.4?46.5)and(87.7?47.8)ng?L-1](all P0.05),as well as Gro-? between the three groups.Conclusion Monocyte may enhance the immune damage in KD pathogenesis,and the levels of IP-10,MCP-1 may be important indexes for KD.Neutrophil may be not involved in pathogenesis of HSP and KD.
