Advances in adenovirus-mediated wild-type p53 gene therapy in human tumors
- VernacularTitle:腺病毒介导的野生型p53基因治疗肿瘤研究进展
- Author:
Xiaohong ZHENG
;
Xiaoping HE
;
Renmin ZHU
- Publication Type:Journal Article
- Keywords:
p53 gene;
Gene therapy,Adenovirus;
Tumor
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Malignant transformation is closely related to gene mutations.The tumor suppressor gene p53 codes for a transcription factor,P53 protein,plays a critical regulation role in oncogene expression,DNA synthesis and repair systems,and cell apoptosis.It has been demonstrated that p53 mutation occurs in more than 50% of cancer cells,which is thought to play a crucial role in malignant transformation.p53-based gene therapeutical approaches in vitro and in vivo aiming at a direct correction of the specific molecular defect in p53-mutated malignant cells,showed notable efficacy in numerous cancer types.In this review,we discussed the current advances in this field,focusing on adenovirus-mediated wild-type p53 gene therapy.
