Nuclear factor kappa B and diabetic retinopathy
- VernacularTitle:核因子-?B在糖尿病视网膜病发病机制中的研究进展
- Author:
Hongjie DI
;
Ming ZHAO
- Publication Type:Journal Article
- Keywords:
Nuclear factor kappa B;
Diabetic retinopathy
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy is a highly specific vascular complication of both type 1 and type 2 diabetes.NF-?B can be triggered by oxidative stress and controls several programs of gene expression,the majority of which participate in the host inflammation and immune response.Evidence has accumulated that NF-?B is involved in the development of diabetic retinopathy.NF-?B activation induced by diabetes is associated with the apoptosis found in the pericyte,leukocyte-endothelial interaction,capillary basement membrane thickening,neovascularization and formation of epiretinal membranes.Inhibition of(NF-?B) activation has been suggested as a treatment strategy in diabetic retinopathy.
