Changes of plasma endothelin, thromboxame B2and 6-keto-PGF1αin patients with coronary heart disease after PTCA
10.3760/cma.j.issn.1673-4130.2009.09.005
- VernacularTitle:经皮冠状动脉成形术后冠心病患者血浆内皮素、血栓素B2、6-酮-前列腺素FL1α水平变化的研究
- Author:
Huabin XIE
;
Yingmin CHEN
;
Zhongying ZHANG
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Angioplasty;
transluminal;
percutaneous coronary;
Endothe-lins;
6-Ketoprostaglandin F1 alpha
- From:
International Journal of Laboratory Medicine
2009;30(9):843-844,847
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the regularity of changes of plasma endothelin (ET), throm-boxame B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) and restenosis after percutaneous transluminal angioplasty (PTCA) in patients with coronary heart disease. Methods Radioimmunoas-say was applied to measuring plasma levels of ET, TXB2and 6-keto-PGF1αat 0,30 min, 1 day and 3 days after PTCA in 41 patients with coronary heart disease. Results The level of ET in the patients with coronary heart disease was significantly decreased in 30 minutes after PTCA (P＜0.05), but no significant difference was observed in 1 day and 3 days after PTCA (P>0.05). The level of plasma TXB2has no statistical difference after PTCA in 30minutes, 1 day and 3 days (P>0.05). The level of 6-keto-prostaglandin F1α(6-keto-PGF1α) of the patients with coronary heart disease was significantly declined in 30 minutes after PTCA (P<0.05) ,but no significant difference was observed in 1 day and 3 days after PTCA (P>0.05). Conclusion PTCA may lead to fluctuation of plasma levels of ET, TXB2and 6-keto-PGF1αThe clarification of changing regularity of these vasoactive substances contrib-utes to prevention of acute artery occlusion or restenosis after PTCA.
