Study on the change of function in blood coagulation and hemostasis system in septicemia patients
- VernacularTitle:败血症患者止凝血功能改变的研究
- Author:
Jianlong MEN
- Publication Type:Journal Article
- Keywords:
Bacteremia;
Blood coagulation;
Anticoagulation;
Fibrinolysis;
Endothelium
- From:
Chinese Journal of Laboratory Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Study on the change of function in coagulation system,anticoagulation system,fibrinolytic system,endothelium system in septicemia patients,and to evaluate the relationship between the change of the parameters and the thrombosis prognosis.Methods The protein C(PC:A),anti- thrombin(AT:A),factor Ⅴ activity(FV:A),factor Ⅶ activity(FⅦ:A),factor Ⅷ activity(FVIH:A), factor Ⅸ activity(FⅨ:A),von Willebrand factor(vWF),fibrinogen(FIB),plasminogen activator inhibitor- 1(PAI-1),D-Dimer,prothrombin time international normalized ratio(PT INR),activated partial thromboplastin time(APTT),and thrombin time(TT)were assayed by the Sysmex CA-7000 blood coagulation instrument in 85 septicemia patients and control group.Results Compared the patients group with the control[ FIB(2 950?870)mg/L,PAI-1(0.6?0.5)Au/ml,vWF(94.1?32.5)%,D-direct (169?94)?g/L,FV:A(97?18)%,FⅦ:A(99?18)%,FⅧ:A(103?22)%,FⅨ:A(102?25)%, PT INR 1.15?0.32,APTT(31?7)s,TT(19?4)s,AT:A(107?9)%,PC:A(101?14)%,t-PA (0.45?0.13)U/ml],the level of the FIB[(3 720?2 290)mg/L],PAI-1[(2.4?1.0)Au/ml],vWF [(167.5?31.2)%],D-Dimer[(355?128)?g/L]were increased obviously(P0.05),the level of the AT:A[(76?17)%],PC:A[(65?19)%],t-PAl(0.22?0.09)U/roll were decreased obviously in patients group(P
