Gadd45a Function in Suppressing Cell Transformation and Tumor Malignancy
- VernacularTitle:Gadd45a在抑制细胞转化和肿瘤恶性进展中的作用
- Author:
Junfang JI
;
Min WU
;
Qimin ZHAN
- Publication Type:Journal Article
- Keywords:
Gadd45a, genomic stability, tumor
- From:
Progress in Biochemistry and Biophysics
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Gadd45a, a p53 and BRCA1-regulated growth arrest and DNA damage gene, plays important roles in suppressing cell transformation and tumor malignancy. Gadd45a maintains the genomic stability through inhibiting the cell growth and promoting the DNA repair etc, by which it suppresses the tumor development. Additionally, Gadd45a is involved in some important signaling pathway, contributing to its function in tumor suppressing.
