Study of The Effect on Islets Cultured In vitro and STZ-induced Diabetic Rats In vivo of EGF-like Domain of Betacellulin
- VernacularTitle:大鼠BTCe对体外培养胰岛保护作用及对糖尿病大鼠降糖作用的研究
- Author:
Hong LI
;
Weibin ZHOU
;
Fengying LI
;
Yanyun GU
;
Jingyan TIAN
;
Lei QIAN
;
Di ZHANG
;
Wenzhong ZHOU
;
Guoting WU
;
Tianhong LUO
;
Guo LI
;
Min LUO
- Publication Type:Journal Article
- Keywords:
betacellulin, cloning, fusion protein, islet, transfection, diabetes mellitus
- From:
Progress in Biochemistry and Biophysics
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Betacellulin (BTC) is one of "islets regeneration factors" which received more and more attention these years. BTCe is the C-terminal 50-residue region of mature BTC protein and can bind with erbB-1?erbB-4 receptor. It has the same mitogenic activity on cells as the whole section. BTC and BTCe can improve the level of glucose-stimulated insulin secretion (GSIS) during islets culture in vitro though they had no effect on the acute insulin secretion. BTCe also effectively ameliorated the hyperglycemia of STZ-induced diabetic rats by a single plasmid injection into muscle of rats. It is supposed that BTCe promote the proliferation of PDX-1 positive cells or repair some signal transduction pathway. Perhaps the latter is more important.
