Homeobox genes CDX1 and CDX2 reduced malignancy of esophageal adenocarcinoma cells
- VernacularTitle:同源异型盒基因CDX1和CDX2使食管腺癌细胞恶性降低
- Author:
Liping MA
;
Na LI
;
Xiuying PAN
;
Jianqiang DONG
;
Xiaoxin CHEN
- Publication Type:Journal Article
- Keywords:
CDX1;
CDX2;
esophageal adenocarcinoma cell;
SEG-1
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of homeobox genes CDX1 and CDX2 on the phenotype of esophageal adenocarcinoma cells.Methods Esophageal adenocarcinoma cell line SEG-1 was transfected with CDX1 or CDX2 cDNA.The morphology,growth rate,division index and tumorigenicity were analyzed.Results The expression of CDX1 or CDX2 leaded to occurring adeniform-like manifestation.The growth rate,division index and tumorigenicity were reduced,especially by CDX2.Conclusion CDX1 and CDX2 all could increase differentiation of esophageal adenocarcinoma cells and reduction of its malignancy.
