Poly-peptide immunogenicity of human thyroid-stimulating hormone receptor that may cause Graves' disease
- VernacularTitle:致Graves病的人促甲状腺激素受体多肽位点筛查
- Author:
Shuwen QIN
;
Ying SHI
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
thyroid-stimulating hormone receptor(TSHR);
human leukocyte antigen(HLA);
Graves' disease(GD)
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
DQA1*0501.TSHR peptides of 183～198、195～210、248～263、301～320、343～362 and 357～376 could bind with high affinity to both HLA-DR3 and HLA-DQA1*0501,all of their IC50 values less than(1 ?mol/L),but they could bind to neither HLA-DR7 nor HLA-DQA1*0201 with high affinity.Conclusion Epitopes of TSHR 183～198,195～210,248～263,301～320,343～362 and 357～376 on the TSHR extracellular domain might be the auto-antigens to cause GD.
