Oxidative damage of H_2O_2 on cultured melanocyte of vitiligo
- VernacularTitle:过氧化氢对白癜风患者黑素细胞的氧化损伤
- Author:
Hong YANG
;
Keyu WANG
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
H_2O_2;
melanocyte;
oxidative stress
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of H_2O_2 on the cultured melanocytes and the relationship between oxidative stress and vitiligo.Method Melanocytes were cultured with H_2O_2,the proliferation and melanogenesis of melanocyte were analysed by MTT and NaOH assay.Result H_2O_2 can inhibite the proliferation and melanogenesis of melanocytes,and the inhibition was concentration and-time-dependent.Conclusion Oxidative stress can inhibite the proliferation and melanogenesis of melanocytes,but oxidative damage can not induce vitiligo.
