The effects of high-dose folic acid on vascular endothelial function in patients with coronary artery disease and undergone interventional therapy
- VernacularTitle:大剂量叶酸对介入治疗后的冠心病患者血管内皮功能的影响
- Author:
Weihong LI
;
Xinheng FENG
;
Guang WANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Endothelial, vascular;
Folic acid
- From:
Chinese Journal of Interventional Cardiology
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate whether High-Dose folic acid supplementation may improve endothelial function in patients with coronary artery disease undergone interventional therapy. Methods Forty six patients with coronary artery disease and undergone interventional therapy were divided into two groups: 23 with folic acid supplement (20 mg/d) and 23 Patients without folic acid as the controls for 6 months. Plasma homocystine (Hcy) was measured by fluorescence polarization immunoassay and Flow-mediated endothelium-dependent dilation (FMD) of the brachial artery was assessed by high resolution ultrasound before and after 6 months. Results Compared with the control, folic acid supplementation resulted in lower plasma Hcy levels (8.82?3.32 ?mol/L vs 13.16?5.06 ?mol/L, P
