Nitroglycerin tolerance aggravates myocardial ischemia reperfusion injury
- VernacularTitle:硝酸甘油耐受对心肌缺血/再灌注损伤影响的研究
- Author:
Qian FAN
;
Lin ZHANG
;
Feng GAO
- Publication Type:Journal Article
- Keywords:
Glyceryl trinitrate;
Drug tolerance;
Myocardial ischemia;
Myocardial reperfusion injury
- From:
Chinese Journal of Interventional Cardiology
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effects of nitroglycerin tolerance on the following myocardial ischemia reperfusion injury (MI/R). Methods Male Sprague-Dawley rats were rardomly subjected to either one of the following treatments: GTN 600 ?g/(kg/h) or saline infusion for 12 h. GTN tolerance was determined with the measurement of mean arterial blood pressure (MABP) and isolated arterial tension. All the GTN-tolerated and the control rats were subjected to 40 min of ischemia followed by 4 h of reperfusion. Myocardial apoptosis (TUNEL analysis), myocardial infarction size (Evans blue-TTC stain), plasma creatine kinase (CK) and lactate dehydrogenase (LDH) activity were determined. Results Nitrate tolerance aggravated MI/R injury as evidenced by increased myocyte apoptosis and infarction size and plasma CK, LDH activity. However, sole GTN tolerance without MI/R injury failed to show any deleterious effect on rat heart. Conclusion GTN tolerance may exert a “potential" deleterious effect on the ischemic hearts.
