Studies on chemical constituents of the sea cucumber Holothuria fuscocinerea
- VernacularTitle:棕环海参化学成分的研究
- Author:
Shuyu ZHANG
- Publication Type:Journal Article
- Keywords:
sea cucumber;
Holothuria fuscocinerea;
triterpene glycosides;
Pyricularia oryzae;
cytotoxicity
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents of the sea cucumber Holothuria fuscocinerea collected from the South China Sea.Methods The compounds were isolated by Pyricularia oryzae bioassay-guided fractionation method in combination with extraction and partition as well as multi-chromatography.Their structures were determined on the basis of spectral analysis and chemical evidence.Results Three triterpene glycosides were isolated from the n-BuOH extract and identified as: pervicoside C(Ⅰ),holothurin A(Ⅱ) and DS-holoturin B(Ⅲ);Four compounds [uracil(Ⅳ),thymine(Ⅴ),thymidine(Ⅵ) and 2'-deoxyuridine(Ⅶ)] were obtained from the CHCl_(3) extract.Conclusion All the compounds were isolated from this sea cucumber for the first time while Compound Ⅰ was first obtained as pure compound.Compound Ⅰ and Ⅱ were active compounds causing morphological abnormality of P.oryzae mycelia and exhibited cytotoxicity against two cancer cell lines.
